Titre Étude de phase III: Radiothérapie par modulation d'intensité préopératoire VS post-opératoire pour les sarcomes des tissus mous du tronc et des extrémités.
Protocole ID RxTx 50/50
ClinicalTrials.gov ID n.d.
Type(s) de cancer Sarcome
Phase Phase III
Type étude Traitement
Institution CIUSSS DE L'EST-DE-L'ILE-DE-MONTREAL
   PAV. MAISONNEUVE/PAV. MARCEL-LAMOUREUX
      5415 boul. de l'Assomption, Montréal, QC, H1T2M4
Ville Montréal
Investigateur(trice) principal(e) Dr Nader Khaouam
Coordonnateur(trice) Jany Barry
514-252-3400
Statut Actif en recrutement
Critètes d'éligibilité
  • Histologically proven soft tissue sarcoma of the extremity or trunk following review by local reference pathologist.
  • Deemed appropriate for preoperative or postoperative radiotherapy and conservative surgery following patient assessment by a radiation oncologist and surgical oncologist.
  • Lesion is primary or locally recurrent. Patient may have undergone excisional biopsy with positive margins at a referring hospital and are eligible following discussion among the surgical oncologists and radiation oncologists that IMRT is an acceptable treatment for that case.
  • ECOG 0-3
  • Patient is aged 18 years or older.
  • Patient is able to provide informed consent
  • Patient is available for treatment and follow-up.
Critètes d'exclusion
  • Benign histology.
  • Prior malignancy within the previous five years or concurrent malignancy with the exception of adequately treated basal cell carcinoma of the skin or carcinoma in-situ of the cervix.
  • Prior radiotherapy to the target site
  • Planned chemotherapy for (neo)adjuvant treatment
  • Conservative surgery to the target site only
  • Presence of regional nodal disease or unequivocal distant metastases.
  • Other major medical illness deemed to preclude safe administration of protocol treatment or required follow-up.